The natural foundation of your beauty!

COLLOST® - the unique collagen material provides the main biological resources of the tissue for the synthesis of new collagen.

The product contains native type I collagen, which is as close as possible to human collagen in composition and structure.

About the product
COLLOST collagen
COLLOST productions

Why is collagen therapy important?

Collagen is the basis of healthy skin

75%

Skin

In youth, collagen turnover is ~6 kg per year

25-33%

Proteins of the body

After age 25–30, collagen content in the skin declines by 20% every 10 years

6%

Body mass

Collagen restorationby middle age, drops to ~3 kg

Decreased collagen in the body

  • Starting from the age of 25, the body's collagen levels begin to decrease.
  • The areas with thin skin and subcutaneous fat (eyelids, neck, hands) are primarily susceptible to aging.

COLLOST® helps in correcting age-related skin atrophy by replenishing collagen deficiency

COLLOST® starts the process of regeneration and renewal of skin cells, stimulating the production of new collagen at 3 levels:

Intact collagen molecule (native collagen)

Structural scaffold for new collagen framework

1

Peptides
(collagen hydrolysate)

Triggers endogenous collagen synthesis

2

Amino acids

Provides building blocks and combats free radicals

3

Advantages of COLLOST®

It stimulates the production of its own collagen, providing a more natural and sustainable rejuvenation result

It contains the maximum concentration of collagen on the world market up to 15%

It allows you to work with thinned skin of the eyelids (up to the ciliary edge), neck, and hands

The unique technologies in the composition increase the firmness and elasticity of the skin without causing puffiness

Provides a long-lasting effect of the procedure (up to 2 years)

COLLOST® has low immunotropic and allergenic activity

Comparison of animal collagens from various sources

Parameter
Cattle
Horse
Marine (fish,
invertebrates)
Recombinant
Identified type
of collagen
I, III
I (SometimesIII)
I (SometimesII, IV)
I, III configurable
Hydroxyproline
(% by weight)
12.5–13.4%
12.5–13.4%
7.1–11.3%
0-13.4%
(depending on the producer)
Proline(% of protein)
12%
12%
8-10%
12%
Denaturation
temperature (Tm)
38–41 °C
37–38.5 °C
20–30 °C
0-13.4%
(depending on the producer)
Solubility (pH7.4, 25 °C)
Average
Average
Very high
Medium/high
Stability under
physiological conditions
Tall
Tall
Medium/low
Medium/high
Parameter Cattle Horse Marine (fish, invertebrates) Recombinant
Identified type of collagen I, III I (Sometimes III) I (Sometimes II, IV) I, III configurable
Hydroxyproline (% by weight) 12.5–13.4% 12.5–13.4% 7.1–11.3% 0-13.4% (depending on the producer)
Proline (% of protein) 12% 12% 8-10% 12%
Denaturation temperature (Tm) 38–41 °C 37–38.5 °C 20–30 °C 0-13.4% (depending on the producer)
Solubility (pH7.4, 25 °C) Average Average Very high Medium/high
Stability under physiological conditions Tall Tall Medium/low Medium/high
Marine collagen has reduced thermal stability and biological activity — due to low hydroxyproline content and absence of Type III collagen. These factors limit its receptor-binding and signaling capability.
Equine collagen is closer to bovine collagen but is mostly Type I — may reduce cell signaling efficacy with cells

Technology and awards

The unique patented MICRONONIC® and PoliONICol® technologies are used for the production of COLLOST® micro.
COLLOST® collagen production technology received a gold medal in the field of medicine at the XXIII International Inventors Exhibition in Geneva (Switzerland).

PoliONICol®
Technology

The technology allows you to enhance the hydrating properties of collagen.

MICRONONIC®
Technology

It is used to increase the biocompatibility of the material.

Indications for use

  • Age and aesthetic skin changes of the face, body, hands, feet of various etiologies
  • Skin thinning, laxity, decreased elasticity
  • Hypertrophic and atrophic scars deformities, including striae
Indications for use Indications for use

Documents and licenses

Registration certificate of COLLOST® micro

Registration certificate of COLLOST® gel

Gulftic-ICSC Halal

Certificate ISO 13485 Austria

ESR Registration certificate

Halal certificate

Certificate ISO 13485

Important questions about COLLOST®

What is COLLOST®, who manufactures it, and in what forms is it available?

COLLOST® is an injectable preparation based on native type I collagen of animal origin, which restructures the skin framework, triggers the synthesis of its own collagen and is a building material for regeneration.

COLLOST® is used in cosmetology to improve the quality of the skin of the face and body, correct scars, including striae, as well as in the treatment of age-related skin changes. It is produced in Russia by BioPHARMAHOLDING, LLC.

It is available in several forms:

COLLOST® gel 7% and 15% — ready-made gel;

COLLOST® micro is a micronized powder.

What is the advantage of COLLOST® over other collagen-containing drugs?

COLLOST® is manufactured using a unique patented technology that preserves the triple-helix structure of the native collagen molecules (meaning its spatial form remains intact). Thanks to this structure, it acts as a matrix for targeted local tissue regeneration, ensuring a pronounced biological effect.

COLLOST® is an injectable preparation with a maximum collagen content ranging from 3% to 15%.

Which collagen is the basis of COLLOST® preparations?

COLLOST® contains native type I collagen of animal origin (bovine collagen), which has undergone multi-stage purification and strict safety control. It holds a Halal certificate.

The scope of COLLOST® in cosmetology?

  • Age-related and aesthetic changes in the soft tissues of the face, body, hands, and legs of various etiologies.
  • Thinning, sagging, decreased elasticity.
  • Hypotrophic and atrophic scar deformations, striae (stretch marks).

What are the main advantages of COLLOST®

  • Contains the maximum concentration of native collagen on the global market, up to 15%.
  • Serves as a material for collagen synthesis ("building blocks"), ensures fibroblast migration, and stimulates the synthesis of the skin's own collagen, leading to skin restructuring.
  • Allows for treatment of thin skin in the eyelid area (up to the lash line), neck, and hands.
  • Unique technologies in the composition increase skin firmness and elasticity without causing swelling.
  • Provides a long-lasting procedural effect.

When will the effect of the procedure be visible?

Stimulation of collagen synthesis begins immediately after the injection. According to normal physiology, a minimum of two weeks is required for the "repair" of collagen fibers.

The first result after the COLLOST® micro procedure can be seen in 3-5 days, while the result after COLLOST® gels can be assessed two weeks after the procedure. The effect of collagen therapy increases over a period of 2-3 months.

How to enhance the effect of collagen therapy In combination with other cosmetic procedures?

Botulinum therapy

Botulinum therapy

Botulinum toxin injections help to relax the facial muscles, which reduces the appearance of wrinkles. When combined with collagen injections, the skin not only becomes smoother but also gains increased firmness and elasticity due to the restoration of its structure.

Plasma Therapy (PRP)

Plasma Therapy (PRP)

Plasmapheresis utilizes the patient's own plasma, enriched with platelets, to stimulate skin regeneration. When combined with collagen injections, this approach enhances regenerative processes, improving skin texture and tone.

Hardware techniques

Hardware techniques

Collagen therapy effectively complements hardware techniques, serving as the preferred procedure for preparing the skin for device-based treatments. It enhances results, promotes accelerated rehabilitation following traumatic procedures, and contributes to achieving a more pronounced effect.

Fillers

Fillers

Fillers, such as hyaluronic acid, are used to fill deep wrinkles and enhance volume in specific areas of the face. Collagen injections can amplify the effects of this procedure by improving skin structure and preventing further aging.

Mesotherapy

Mesotherapy

This procedure involves injecting hyaluronic acid along with nutrient cocktails containing vitamins, amino acids, and other active compounds into the skin. When combined with collagen injections, mesotherapy enhances rejuvenation effects, improves skin texture and tone, while restoring the skin's natural barrier and providing deep hydration.

Before/After

Any other questions?

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